Shanghai Nianxing Industrial Co., Ltd
China
Product Name: marmesin
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Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: marmesin
Price: ￥2748.0/10mg
Purity: 98.0%
Stocking Period: 2 Day
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DC Chemicals Limited
China
Product Name: Marmesin
Price: $700.0/100mg $1200.0/250mg $2500.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Marmesin
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

13849-08-6

13849-08-6 structure

13849-08-6 structure

Name: marmesin
Chemical Name: (+)-marmesin
CAS Number: 13849-08-6
Molecular Formula: C₁₄H₁₄O₄
Molecular Weight: 246.259
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-08-28 18:31:08
Modify Date: 2024-01-02 18:58:50
S-(+)-Marmesin is a natural coumarin, exhibiting COX-2/5-LOX dual inhibitory activity.

Name	(+)-marmesin
Synonyms	2-(2-Hydroxy-2-propanyl)-2,3-dihydro-7H-furo[3,2-g]chromen-7-one 2,3-dihydro-2-(1-hydroxy-1-methylethyl)-7H-furo[3,2-g][1]benzopyran-7-one (7S)-marmesin marmesin 2-(2-hydroxypropan-2-yl)-2,3-dihydro-7H-furo[3,2-g]chromen-7-one 7H-Furo[3,2-g][1]benzopyran-7-one, 2,3-dihydro-2-(1-hydroxy-1-methylethyl)- 2-(1-Hydroxy-1-methyl-ethyl)-2,3-dihydro-furo[3,2-g]chromen-7-one S(+)-Marmesin 2-(1-Hydroxy-1-methylethyl)-2,3-dihydrofuro[3,2-g]chromen-7-one (2S)-2-(2-hydroxypropan-2-yl)-2,3-dihydrofuro[3,2-g]chromen-7-one S-(+)-Marmesin

Description	S-(+)-Marmesin is a natural coumarin, exhibiting COX-2/5-LOX dual inhibitory activity.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase Research Areas >> Others Natural Products >> Phenylpropanoids
Target	COX-2 5-Lipoxygenase
In Vitro	S-(+)-Marmesin ((+)-marmesin) shows affinity at the recombinant psoralen synthase, with a Km of 1.5 ± 0.5 μM, exceeding the substrate affinities of other enzymes of the CYP71 subfamily involved in plant secondary metabolism[1]. S-(+)-Marmesin ((+)-marmesin) shows COX-2/5-LOX dual inhibitory activity[2].
References	[1]. Larbat R, et al. Molecular cloning and functional characterization of psoralen synthase, the first committed monooxygenase of furanocoumarin biosynthesis. J Biol Chem. 2007 Jan 5;282(1):542-54. Epub 2006 Oct 26. [2]. Kim JS, et al. Chemical constituents of the root of Dystaenia takeshimana and their anti-inflammatory activity. Arch Pharm Res. 2006 Aug;29(8):617-23.

Density	1.3±0.1 g/cm3
Boiling Point	434.0±45.0 °C at 760 mmHg
Melting Point	189-191℃
Molecular Formula	C₁₄H₁₄O₄
Molecular Weight	246.259
Flash Point	168.0±22.2 °C
Exact Mass	246.089203
PSA	59.67000
LogP	1.69
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.611
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV1045500

CHEMICAL NAME :: 7H-Furo(3,2-g)(1)benzopyran-7-one, 2,3-dihydro-2-(1-hydroxy-1-methylethyl)-, (S)-(+)-

CAS REGISTRY NUMBER :: 13849-08-6

LAST UPDATED :: 199410

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H14-O4

MOLECULAR WEIGHT :: 246.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1040 ng/plate

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 13,521,1984