1414854-42-4

1414854-42-4 structure

Name: Verosudil(AR-12286)
Chemical Name: verosudil
CAS Number: 1414854-42-4
Molecular Formula: C₁₇H₁₇N₃O₂S
Molecular Weight: 327.401
Catalog: Signaling Pathways Cell Cycle/DNA Damage ROCK
Create Date: 2018-10-17 08:21:56
Modify Date: 2024-01-08 11:58:54
Verosudil (AR-12286) is a potent, selective Rho-kinase (ROCK) inhibitor with Kis of 2 and 2 nM for ROCK1 and ROCK2, respectively. AR-12286 lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork[1][2].

Name	verosudil
Synonyms	verosudil UNII:MAF34143WM 2-(Dimethylamino)-N-(1-oxo-1,2-dihydro-6-isoquinolinyl)-2-(3-thienyl)acetamide 3-Thiopheneacetamide, N-(1,2-dihydro-1-oxo-6-isoquinolinyl)-α-(dimethylamino)- UNII: MAF34143WM AR-12286 MAF34143WM

Description	Verosudil (AR-12286) is a potent, selective Rho-kinase (ROCK) inhibitor with Kis of 2 and 2 nM for ROCK1 and ROCK2, respectively. AR-12286 lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork[1][2].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK Research Areas >> Neurological Disease Signaling Pathways >> Stem Cell/Wnt >> ROCK Signaling Pathways >> TGF-beta/Smad >> ROCK
Target	ROCK1:2 nM (Ki) ROCK2:2 nM (Ki) PKA:69 nM (Ki) MRCKA:28 nM (Ki) CAM2A:5855 nM (Ki) PKC theta:9322 nM (Ki)
References	[1]. Lin CW, Sherman B, Moore LA, et al. Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma. J Ocul Pharmacol Ther. 2018;34(1-2):40‐51. [2]. Kopczynski C, Novack GD, Swearingen D, van Haarlem T. Ocular hypotensive efficacy, safety and systemic absorption of AR-12286 ophthalmic solution in normal volunteers. Br J Ophthalmol. 2013;97(5):567‐572.