1889336-59-7
1889336-59-7 structure
- Name: MNK inhibitor 9
- Chemical Name: MNK inhibitor 9
- CAS Number: 1889336-59-7
- Molecular Formula: C25H29N9O
- Molecular Weight: 471.569
- Catalog: Signaling Pathways MAPK/ERK Pathway MNK
- Create Date: 2020-01-19 17:15:33
- Modify Date: 2024-01-06 11:42:00
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MNK inhibitor 9 is a potent, selective MAPK-interacting kinase (MNK1 and MNK2) inhibitor with IC50 of 3 nM for both, with no activity aginst CDK1/2 (IC50>25 uM); displays excellent selectivity against a 53 kinase panel, with 4 kinases with IC50 <1 uM; inhibits eIF4E phosphorylation in KMS11-luc myeloma with IC50 of 0.6 nM, exhibits inhibition of cell proliferation in human multiple myeloma tumor cell line with EC50 of 1.7 uM; has good solubility and permeability, and is a suitable in vivo tool compound.
| Name | MNK inhibitor 9 |
|---|
| Description | MNK inhibitor 9 is a potent, selective MAPK-interacting kinase (MNK1 and MNK2) inhibitor with IC50 of 3 nM for both, with no activity aginst CDK1/2 (IC50>25 uM); displays excellent selectivity against a 53 kinase panel, with 4 kinases with IC50 <1 uM; inhibits eIF4E phosphorylation in KMS11-luc myeloma with IC50 of 0.6 nM, exhibits inhibition of cell proliferation in human multiple myeloma tumor cell line with EC50 of 1.7 uM; has good solubility and permeability, and is a suitable in vivo tool compound. |
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| References | References 1. Han W, et al. J Med Chem. 2016 Apr 14;59(7):3034-45. View Related Products by Target MNK |
| Molecular Formula | C25H29N9O |
|---|---|
| Molecular Weight | 471.569 |