1889336-59-7

1889336-59-7 structure

Name: MNK inhibitor 9
Chemical Name: MNK inhibitor 9
CAS Number: 1889336-59-7
Molecular Formula: C₂₅H₂₉N₉O
Molecular Weight: 471.569
Catalog: Signaling Pathways MAPK/ERK Pathway MNK
Create Date: 2020-01-19 17:15:33
Modify Date: 2024-01-06 11:42:00
MNK inhibitor 9 is a potent, selective MAPK-interacting kinase (MNK1 and MNK2) inhibitor with IC50 of 3 nM for both, with no activity aginst CDK1/2 (IC50>25 uM); displays excellent selectivity against a 53 kinase panel, with 4 kinases with IC50 <1 uM; inhibits eIF4E phosphorylation in KMS11-luc myeloma with IC50 of 0.6 nM, exhibits inhibition of cell proliferation in human multiple myeloma tumor cell line with EC50 of 1.7 uM; has good solubility and permeability, and is a suitable in vivo tool compound.

Name	MNK inhibitor 9

Description	MNK inhibitor 9 is a potent, selective MAPK-interacting kinase (MNK1 and MNK2) inhibitor with IC50 of 3 nM for both, with no activity aginst CDK1/2 (IC50>25 uM); displays excellent selectivity against a 53 kinase panel, with 4 kinases with IC50 <1 uM; inhibits eIF4E phosphorylation in KMS11-luc myeloma with IC50 of 0.6 nM, exhibits inhibition of cell proliferation in human multiple myeloma tumor cell line with EC50 of 1.7 uM; has good solubility and permeability, and is a suitable in vivo tool compound.
References	References 1. Han W, et al. J Med Chem. 2016 Apr 14;59(7):3034-45. View Related Products by Target MNK

Molecular Formula	C₂₅H₂₉N₉O
Molecular Weight	471.569