408305-09-9

408305-09-9 structure

Name: Ac-RYYRWK-NH2 TFA
Chemical Name: Ac-RYYRWK-NH2 TFA
CAS Number: 408305-09-9
Molecular Formula: C₅₁H₇₀F₃N₁₅O₁₁
Molecular Weight: 1126.19
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2020-08-11 18:09:18
Modify Date: 2024-01-02 12:12:22
Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [3H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a Kd of 0.071 nM, but has no affinity for µ-, κ- or δ-opioid receptors[1].

Name	Ac-RYYRWK-NH2 TFA

Description	Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [3H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a Kd of 0.071 nM, but has no affinity for µ-, κ- or δ-opioid receptors[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
In Vitro	[3H]ac-RYYRWK-NH2 binding to rat cortical membranes revealed a single high affinity site for [3H]ac-RYYRWK-NH2 (Kd=0.071 nM)[1]. Naloxone benzoylhydrazone displaced [3H]acRYYRWK-NH2 binding to rat cortical membranes (Ki=104 nM) and human ORL1 (Ki=136 nM) as well as [125I]Tyr14-NC-OH to ORL1 (Ki=37 nM) has no affinity for µ-, κ- or δ-opioid receptors[1].
References	[1]. C T Dooley, et al. Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1.J Pharmacol Exp Ther. 1997 Nov;283(2):735-41. [2]. M Ho, et al, Characterization of the ORL(1) receptor on adrenergic nerves in the rat anococcygeus muscle. Br J Pharmacol. 2000 Sep;131(2):349-55.

Molecular Formula	C₅₁H₇₀F₃N₁₅O₁₁
Molecular Weight	1126.19