2407521-90-6

2407521-90-6 structure

Name: Topoisomerase IIα-IN-2
Chemical Name: Topoisomerase IIα-IN-2
CAS Number: 2407521-90-6
Molecular Formula: C₂₂H₂₀N₄O₅
Molecular Weight: 420.42
Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
Create Date: 2022-07-01 15:25:33
Modify Date: 2024-01-12 11:32:19
Topoisomerase IIα-IN-2 (compound 5) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-2 exhibits high antiproliferative activity against human cancer cell lines. Topoisomerase IIα-IN-2 significantly induces DNA damage and arrests cancer cells at G2/M phase[1].

Name	Topoisomerase IIα-IN-2

Description	Topoisomerase IIα-IN-2 (compound 5) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-2 exhibits high antiproliferative activity against human cancer cell lines. Topoisomerase IIα-IN-2 significantly induces DNA damage and arrests cancer cells at G2/M phase[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	topoisomerase II alpha topoisomerase II beta
In Vitro	Topoisomerase IIα-IN-2 (compound 5) shows antiproliferative activity in cancer cell lines (CCRF-CEM, CCRF-SB, MT-4, HT-29, MCF-7, HeLa, ACHN, SKMEL-28, and G-361), with IC50 values of 0.003, 0.005, 0.006, 0.004, 0.003, 0.005, 0.005, 0.002, and 0.006 μM, respectively[1].
References	[1]. Pedatella S, et al. Antitumor agents 7. Synthesis, antiproliferative activity and molecular modeling of new l-lysine-conjugated pyridophenoxazinones as potent DNA-binding ligands and topoisomerase IIα inhibitors. Eur J Med Chem. 2020 Feb 1;187:111960.

Molecular Formula	C₂₂H₂₀N₄O₅
Molecular Weight	420.42