2407521-87-1

2407521-87-1 structure

Name: Topoisomerase IIα-IN-1
Chemical Name: Topoisomerase IIα-IN-1
CAS Number: 2407521-87-1
Molecular Formula: C₂₂H₂₀N₄O₅
Molecular Weight: 420.42
Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
Create Date: 2022-07-02 16:40:39
Modify Date: 2024-01-17 17:11:13
Topoisomerase IIα-IN-1 (compound 2) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-1 exhibits high antiproliferative activity against human cancer cell lines[1].

Name	Topoisomerase IIα-IN-1

Description	Topoisomerase IIα-IN-1 (compound 2) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-1 exhibits high antiproliferative activity against human cancer cell lines[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	topoisomerase II alpha topoisomerase II beta
In Vitro	Topoisomerase IIα-IN-1 (compound 2) shows antiproliferative activity in cancer cell lines (CCRF-CEM, CCRF-SB, MT-4, HT-29, MCF-7, HeLa, ACHN, SKMEL-28, and G-361), with IC50 values of 0.02, 0.02, 0.01, 0.003, 0.007, 0.005, 0.008, 0.002, and 0.001 μM, respectively[1].
References	[1]. Pedatella S, et al. Antitumor agents 7. Synthesis, antiproliferative activity and molecular modeling of new l-lysine-conjugated pyridophenoxazinones as potent DNA-binding ligands and topoisomerase IIα inhibitors. Eur J Med Chem. 2020 Feb 1;187:111960.

Molecular Formula	C₂₂H₂₀N₄O₅
Molecular Weight	420.42