Topoisomerase IIα-IN-1

Modify Date: 2024-01-17 17:11:13

Topoisomerase IIα-IN-1 structure	Common Name	Topoisomerase IIα-IN-1
	CAS Number	2407521-87-1	Molecular Weight	420.42
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₀N₄O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Topoisomerase IIα-IN-1

Topoisomerase IIα-IN-1 (compound 2) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-1 exhibits high antiproliferative activity against human cancer cell lines[1].

Name	Topoisomerase IIα-IN-1

Description	Topoisomerase IIα-IN-1 (compound 2) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-1 exhibits high antiproliferative activity against human cancer cell lines[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	topoisomerase II alpha topoisomerase II beta
In Vitro	Topoisomerase IIα-IN-1 (compound 2) shows antiproliferative activity in cancer cell lines (CCRF-CEM, CCRF-SB, MT-4, HT-29, MCF-7, HeLa, ACHN, SKMEL-28, and G-361), with IC50 values of 0.02, 0.02, 0.01, 0.003, 0.007, 0.005, 0.008, 0.002, and 0.001 μM, respectively[1].
References	[1]. Pedatella S, et al. Antitumor agents 7. Synthesis, antiproliferative activity and molecular modeling of new l-lysine-conjugated pyridophenoxazinones as potent DNA-binding ligands and topoisomerase IIα inhibitors. Eur J Med Chem. 2020 Feb 1;187:111960.

Molecular Formula	C₂₂H₂₀N₄O₅
Molecular Weight	420.42