Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ODN 1668
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Purity: 99.0%
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1186063-66-0

1186063-66-0 structure

1186063-66-0 structure

Name: ODN 1668
Chemical Name: ODN 1668
CAS Number: 1186063-66-0
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
Create Date: 2022-09-04 11:55:53
Modify Date: 2024-01-11 13:28:50
ODN 1668, a class B CpG ODN (oligodeoxynucleotide), is a TLR-9 agonist. ODN 1668 is an immunostimulatory sequence and can be used as vaccine adjuvant. Sequence: 5'-tccatgacgttcctgatgct-3’[1][2].

Name	ODN 1668

Description	ODN 1668, a class B CpG ODN (oligodeoxynucleotide), is a TLR-9 agonist. ODN 1668 is an immunostimulatory sequence and can be used as vaccine adjuvant. Sequence: 5'-tccatgacgttcctgatgct-3’[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Inflammation/Immunology
Target	TLR9
In Vitro	ODN 1668 induces TNF-α secretion and promotes polyclonal B cell activation[1].
In Vivo	ODN 1668 (10 nmol) stimulates responses to protein antigen[1]. ODN 1668 (1 or 5 mg/kg; i.p. or s.c.; once) causes moderate fever and anorexia in rats[2]. Animal Model: C57BW6 mice[1] Dosage: 10 nmol Administration: 300 μg OVA (ovalbumin) in PBS or liposomes containing OVA were injected with or without 10nmol ODN in the hind footpads of C57BW6 mice. A boost of the sameinoculum was given at 2 weeks, and 1 week later blood was taken for serum antibody titering. Result: Strongly potentiated the antibody response and induced class switching toward IgG2a and IgG2b. Showed B cell blast formation and a more than twofold increase in B7.2 (CD86) and IL-2 receptor-α (CD25) surface expression. Animal Model: Male Wistar rats with body weights in the range of 175–200 g[2] Dosage: 1 mg/kg or 5 mg/kg Administration: Intraperitoneal and subcutaneous injection, once Result: Caused moderate fever and anorexia. Induced a significant increase of IL-6. Increased expression of inflammatory genes and activated inflammatory transcription factors.
References	[1]. Lipford GB, et al. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants. Eur J Immunol. 1997 Sep;27(9):2340-4. [2]. Damm J, et al. Intraperitoneal and subcutaneous injections of the TLR9 agonist ODN 1668 in rats: brain inflammatory responses are related to peripheral IL-6 rather than interferons. J Neuroimmunol. 2014 Dec 15;277(1-2):105-17.

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