1965342-40-8

1965342-40-8 structure

1965342-40-8 structure

Name: ODN 105870
Chemical Name: ODN 105870
CAS Number: 1965342-40-8
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
Create Date: 2023-02-16 17:40:10
Modify Date: 2024-04-02 23:08:53
ODN 105870, a G-modified inhibitory oligonucleotide (INH-ODN), is a selective TLR7 inhibitor. ODN 105870 can be uesd for inflammatory immune responses research[1].

Name	ODN 105870

Description	ODN 105870, a G-modified inhibitory oligonucleotide (INH-ODN), is a selective TLR7 inhibitor. ODN 105870 can be uesd for inflammatory immune responses research[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Inflammation/Immunology
In Vitro	ODN 105870 potently inhibits the TLR7-induced TNF-α response in bone marrow-derived macrophages (BMDMs)[1]. In case of Imiquimod-stimulated B cells, ODN 105870 (10 μM) reduces the ATP content to the pretreatment level[1].
References	[1]. Franziska Römmler, et al. Guanine modification of inhibitory oligonucleotides potentiates their suppressive function. J Immunol. 2013 Sep 15;191(6):3240-53.

No Any Chemical & Physical Properties