1964506-29-3

1964506-29-3 structure

Name: ODN 20844
Chemical Name: ODN 20844
CAS Number: 1964506-29-3
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
Create Date: 2022-09-04 11:20:51
Modify Date: 2024-04-05 20:06:03
ODN 20844, a guanine-modified inhibitory oligonucleotide (INH-ODN), is a TLR7 and TLR9 (Toll-like receptor) inhibitor, and its parent is INH-ODN 2088. ODN 20844 disrupts TLR7- and TLR9-mediated immune cell immune responses. ODN 20844 sequence: 5'-TCCTGGCGc7GGGAAGT-3'[1].

Name	ODN 20844

Description	ODN 20844, a guanine-modified inhibitory oligonucleotide (INH-ODN), is a TLR7 and TLR9 (Toll-like receptor) inhibitor, and its parent is INH-ODN 2088. ODN 20844 disrupts TLR7- and TLR9-mediated immune cell immune responses. ODN 20844 sequence: 5'-TCCTGGCGc7GGGAAGT-3'[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Infection Research Areas >> Inflammation/Immunology
Target	TLR7 TLR9
In Vitro	ODN 20844 (0.01-10 μM, 24 h) can effectively block TLR9-mediated IFN-α release and inhibit IL-6 secretion in human peripheral blood mononuclear cells[1]. ODN 20844 (0.01-10 μM, 24 h) has better inhibitory effect on imiquimod-induced IL-6 secretion in human B cells than INH-ODN 2088[1].
References	[1]. Franziska Römmler, et al. Guanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cells. PLoS One. 2015 Feb 19;10(2):e0116703.

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