Name | Aha1/Hsp90-IN-1 |
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Description | Aha1/Hsp90-IN-1 (Compound 17) is an Aha1/Hsp90 complex inhibitor. Aha1/Hsp90-IN-1 disrupts Aha1/Hsp90 interactions with an IC50 of 3.32 μM. Aha1/Hsp90-IN-1 inhibits tau aggregation[1]. |
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Related Catalog | |
Target |
IC50: 3.32 μM (Aha1/Hsp90 interactions)[1] |
In Vitro | Aha1/Hsp90-IN-1 (Compound 17) (10 μM; 24 h) disrupts the Aha1/Hsp90 complex without direct inhibition of Hsp90 protein folding activity[1]. Western Blot Analysis[1] Cell Line: SH-SY5Y neuroblastoma cells and Her2 overexpressing SK-BR-3 breast cancer cells Concentration: 10 μM Incubation Time: 24 h Result: Exhibited the ability to disrupt interactions between Aha1 and Hsp90. Did not induce the degradation of Hsp90 client proteins Her2 (in SK-BR-3 cells), Cdk6, or pAktS473 (in SH SY5Y cells), nor do they induce the expression of Hsp70, a marker of the heat shock response. |
References |
Molecular Formula | C22H17F3N4O2 |
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Molecular Weight | 426.39 |