2411955-43-4

2411955-43-4 structure

Name: HDAC6/HSP90-IN-1
Chemical Name: HDAC6/HSP90-IN-1
CAS Number: 2411955-43-4
Molecular Formula: C₂₈H₃₇N₃O₆
Molecular Weight: 511.61
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2022-07-01 14:18:39
Modify Date: 2024-01-05 08:20:40
HDAC6/HSP90-IN-1 (compound 17) is a potent and selective dual inhibitor of HDAC6 and HSP90, with IC50 values of 4.3 and 46.8 nM, respectively. HDAC6/HSP90-IN-1 down-regulates PD-L1 expression in INF-γ treated H1975 lung cancer cells. HDAC6/HSP90-IN-1 inhibits tumor growth in human H1975 xenograft mice[1].

Name	HDAC6/HSP90-IN-1

Description	HDAC6/HSP90-IN-1 (compound 17) is a potent and selective dual inhibitor of HDAC6 and HSP90, with IC50 values of 4.3 and 46.8 nM, respectively. HDAC6/HSP90-IN-1 down-regulates PD-L1 expression in INF-γ treated H1975 lung cancer cells. HDAC6/HSP90-IN-1 inhibits tumor growth in human H1975 xenograft mice[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Signaling Pathways >> Cell Cycle/DNA Damage >> HSP Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC6:4.32 nM (IC50) HSP90:46.8 nM (IC50) HDAC3:1312 nM (IC50) HDAC1:1878 nM (IC50) HDAC8:3720 nM (IC50)
References	[1]. Ojha R, et al. Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo. Eur J Med Chem. 2020 Mar 15;190:112086.

Molecular Formula	C₂₈H₃₇N₃O₆
Molecular Weight	511.61