2484255-65-2

2484255-65-2 structure

Name: HDAC6/8/BRPF1-IN-1
Chemical Name: HDAC6/8/BRPF1-IN-1
CAS Number: 2484255-65-2
Molecular Formula: C₁₈H₁₇N₃O₅S
Molecular Weight: 387.41
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2022-10-15 20:45:39
Modify Date: 2024-04-05 18:51:19
HDAC6/8/BRPF1-IN-1 is a dual inhibitor of both HDAC6/8 and the bromodomain and PHD finger containing protein 1 (BRPF1). HDAC6/8/BRPF1-IN-1 has inhibitory activity for HDAC1, HDAC6 and HDAC8 with IC50 values of 797 nM, 344 nM and 908 nM, respectively. HDAC6/8/BRPF1-IN-1 has inhibitory activity for BRPF1 with an Kd value of 175.2 nM. HDAC6/8/BRPF1-IN-1 can be used for the research of cancer[1].

Name	HDAC6/8/BRPF1-IN-1

Description	HDAC6/8/BRPF1-IN-1 is a dual inhibitor of both HDAC6/8 and the bromodomain and PHD finger containing protein 1 (BRPF1). HDAC6/8/BRPF1-IN-1 has inhibitory activity for HDAC1, HDAC6 and HDAC8 with IC50 values of 797 nM, 344 nM and 908 nM, respectively. HDAC6/8/BRPF1-IN-1 has inhibitory activity for BRPF1 with an Kd value of 175.2 nM. HDAC6/8/BRPF1-IN-1 can be used for the research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC1:797 nM (IC50) HDAC6:344 nM (IC50) HDAC8:908 nM (IC50)
In Vitro	HDAC6/8/BRPF1-IN-1 has inhibitory activity for HDAC1, HDAC6 and HDAC8 with IC50 values of 797 nM, 344 nM and 908 nM, respectively[1]. HDAC6/8/BRPF1-IN-1 has inhibitory activity for BRPF1 with an Kd value of 175.2 nM[1].
References	[1]. Ehab Ghazy, et al. Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1. Eur J Med Chem. 2020 Aug 15;200:112338.

Molecular Formula	C₁₈H₁₇N₃O₅S
Molecular Weight	387.41