2307277-93-4
2307277-93-4 structure
- Name: LRRK2-IN-7
- Chemical Name: LRRK2-IN-7
- CAS Number: 2307277-93-4
- Molecular Formula: C24H26N6O
- Molecular Weight: 414.50
- Catalog: Signaling Pathways Autophagy LRRK2
- Create Date: 2023-01-31 16:06:01
- Modify Date: 2024-04-10 19:11:09
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LRRK2-IN-7 is a potent, selective, and CNS-penetrant LRRK2 kinase inhibitor with an IC50 of 0.9 nM. LRRK2-IN-7 shows >1000-fold selectivity over other kinases, ion channels, and CYP enzymes[1].
| Name | LRRK2-IN-7 |
|---|
| Description | LRRK2-IN-7 is a potent, selective, and CNS-penetrant LRRK2 kinase inhibitor with an IC50 of 0.9 nM. LRRK2-IN-7 shows >1000-fold selectivity over other kinases, ion channels, and CYP enzymes[1]. |
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| Related Catalog | |
| Target |
IC50: 0.9 nM (LRRK2 Kinase)[1] |
| In Vitro | LRRK2-IN-7 (compound 25) 既是小鼠乳腺癌抗性蛋白 (BCRP) 底物（小鼠/人 BCRP）也是一种有效的人 BCRP 抑制剂（BCRP IC50 = 0.12 μM）[1] . |
| In Vivo | 在一项为期 7 天的大鼠剂量限制毒性研究中，LRRK2-IN-7 (compound 25) 的耐受性高达 100 mg/kg，每天一次（AUCtot = 330 μM·h）[1]。 在大鼠急性（2 小时）PK/PD 研究中，LRRK2-IN-7 (compound 25) 显示大鼠脑纹状体中 LRRK2 pS935 剂量依赖性降低，EC50 = 0.18 nM[1]。 |
| References |
| Molecular Formula | C24H26N6O |
|---|---|
| Molecular Weight | 414.50 |