2641054-59-1

2641054-59-1 structure
2641054-59-1 structure
  • Name: LRRK2-IN-4
  • Chemical Name: LRRK2-IN-4
  • CAS Number: 2641054-59-1
  • Molecular Formula: C25H29ClF2N6O2
  • Molecular Weight: 518.99
  • Catalog: Signaling Pathways Autophagy LRRK2
  • Create Date: 2022-05-22 15:03:14
  • Modify Date: 2024-01-12 20:18:08
  • LRRK2-IN-4 is a potent, selective, CNS-penetran and orally active leucine-rich repeat kinase 2 (LRRK2) inhobitor with an IC50 of 2.6 nM. LRRK2-IN-4 has the potential for the research of Parkinson’s disease[1].

Name LRRK2-IN-4
Description LRRK2-IN-4 is a potent, selective, CNS-penetran and orally active leucine-rich repeat kinase 2 (LRRK2) inhobitor with an IC50 of 2.6 nM. LRRK2-IN-4 has the potential for the research of Parkinson’s disease[1].
Related Catalog
Target

IC50: 2.6 nM (LRRK2)[1]

In Vivo LRRK2-IN-4 (compound 24) (p.o.) shows good oral bioavailability in male Wistar-Han rats (F=64%), male beagle dogs (F=65%)[1].
References

[1]. Keylor MH, et al. Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors. J Med Chem. 2022; 65(1):838-856.

Molecular Formula C25H29ClF2N6O2
Molecular Weight 518.99