LRRK2-IN-4

Modify Date: 2024-01-12 20:18:08

LRRK2-IN-4 structure	Common Name	LRRK2-IN-4
	CAS Number	2641054-59-1	Molecular Weight	518.99
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₉ClF₂N₆O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of LRRK2-IN-4

LRRK2-IN-4 is a potent, selective, CNS-penetran and orally active leucine-rich repeat kinase 2 (LRRK2) inhobitor with an IC50 of 2.6 nM. LRRK2-IN-4 has the potential for the research of Parkinson’s disease[1].

Name	LRRK2-IN-4

Description	LRRK2-IN-4 is a potent, selective, CNS-penetran and orally active leucine-rich repeat kinase 2 (LRRK2) inhobitor with an IC50 of 2.6 nM. LRRK2-IN-4 has the potential for the research of Parkinson’s disease[1].
Related Catalog	Signaling Pathways >> Autophagy >> LRRK2 Research Areas >> Neurological Disease
Target	IC50: 2.6 nM (LRRK2)[1]
In Vivo	LRRK2-IN-4 (compound 24) (p.o.) shows good oral bioavailability in male Wistar-Han rats (F=64%), male beagle dogs (F=65%)[1].
References	[1]. Keylor MH, et al. Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors. J Med Chem. 2022; 65(1):838-856.

Molecular Formula	C₂₅H₂₉ClF₂N₆O₂
Molecular Weight	518.99