LRRK2-IN-3

Modify Date: 2024-01-11 08:18:06

LRRK2-IN-3 Structure
LRRK2-IN-3 structure
Common Name LRRK2-IN-3
CAS Number 2641054-60-4 Molecular Weight 518.99
Density N/A Boiling Point N/A
Molecular Formula C25H29ClF2N6O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LRRK2-IN-3


LRRK2-IN-3 (compoubd 24) is a potent, selective, orally active and brain-penetrant inhibitor LRRK2, with IC50 of 2.6 nM in human PBMCs. LRRK2-IN-3 can be used for the research of Parkinson's disease[1].

 Names

Name LRRK2-IN-3

 LRRK2-IN-3 Biological Activity

Description LRRK2-IN-3 (compoubd 24) is a potent, selective, orally active and brain-penetrant inhibitor LRRK2, with IC50 of 2.6 nM in human PBMCs. LRRK2-IN-3 can be used for the research of Parkinson's disease[1].
Related Catalog
Target

IC50: 2.6 nM (hPBMCs LRRK2)[1]

References

[1]. Keylor MH, et, al. Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors. J Med Chem. 2022 Jan 13;65(1):838-856.

 Chemical & Physical Properties

Molecular Formula C25H29ClF2N6O2
Molecular Weight 518.99