2869954-34-5

2869954-34-5 structure

Name: Werner syndrome RecQ helicase-IN-1
Chemical Name: Werner syndrome RecQ helicase-IN-1
CAS Number: 2869954-34-5
Molecular Formula: C₃₁H₃₁ClF₃N₉O₅
Molecular Weight: 702.08
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2023-04-14 12:57:00
Modify Date: 2024-04-06 10:11:13
Werner syndrome RecQ helicase-IN-1 (example 42) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research[1].

Name	Werner syndrome RecQ helicase-IN-1

Description	Werner syndrome RecQ helicase-IN-1 (example 42) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vitro	Werner syndrome RecQ helicase-IN-1(example 42)作用于 WRN ATPase 的 IC50 值为100 nM，作用于 SW48 和 DLD1 WRN-KO 细胞系的 GI50 值分别是 50 nM和大于10 μM[1]。
References	[1]. Triazolo-pyrimidine analogues for treating diseases connected to the inhibiton of werner syndrome recq helicase (wrn). WO2022249060

Molecular Formula	C₃₁H₃₁ClF₃N₉O₅
Molecular Weight	702.08