2869954-51-6

2869954-51-6 structure

Name: Werner syndrome RecQ helicase-IN-2
Chemical Name: Werner syndrome RecQ helicase-IN-2
CAS Number: 2869954-51-6
Molecular Formula: C₃₂H₃₄F₃N₉O₅
Molecular Weight: 681.66
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2023-04-06 10:40:48
Modify Date: 2024-04-06 19:08:17
Werner syndrome RecQ helicase-IN-2 (example 57) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research[1].

Name	Werner syndrome RecQ helicase-IN-2

Description	Werner syndrome RecQ helicase-IN-2 (example 57) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vitro	Werner syndrome RecQ helicase-IN-2 (example 57)作用于 WRN ATPase 的IC50 值为100 nM，作用于 SW48和 DLD1 WRN-KO 细胞系的GI50 值分别是100 nM和大于10 μM[1]。
References	[1]. Triazolo-pyrimidine analogues for treating diseases connected to the inhibiton of werner syndrome recq helicase (wrn). WO2022249060

Molecular Formula	C₃₂H₃₄F₃N₉O₅
Molecular Weight	681.66