2869954-98-1
2869954-98-1 structure
- Name: Werner syndrome RecQ helicase-IN-3
- Chemical Name: Werner syndrome RecQ helicase-IN-3
- CAS Number: 2869954-98-1
- Molecular Formula: C31H30ClF3N8O5
- Molecular Weight: 687.07
- Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
- Create Date: 2023-04-04 20:12:57
- Modify Date: 2024-04-05 19:47:06
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Werner syndrome RecQ helicase-IN-3 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 µM. Werner syndrome RecQ helicase-IN-3 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-3 shows anticancer activity[1].
| Name | Werner syndrome RecQ helicase-IN-3 |
|---|
| Description | Werner syndrome RecQ helicase-IN-3 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 µM. Werner syndrome RecQ helicase-IN-3 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-3 shows anticancer activity[1]. |
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| Related Catalog | |
| Target |
IC50: 0.06 µM (WRN)[1] |
| In Vitro | Werner syndrome RecQ helicase-IN-3 (example 96) (0-10 µM; 8-20 days) 显示抗增殖活性，对 SW48，DLD1 WRN-KO 细胞的 GI50s 值分别为 0.06，>10 µM[1]。 Cell Proliferation Assay[1] Cell Line: SW48, DLD1 WRN-KO cells Concentration: 0-10 µM Incubation Time: 8-20 days Result: Showed antiproliferative activity with GI50s of 0.06, >10 µM for SW48, DLD1 WRN-KO cells, respectively. |
| In Vivo | Werner syndrome RecQ helicase-IN-3 (120 mg/kg; daily for 22 days) 在小鼠体内显示出抗癌活性[1]。 Animal Model: Female Crl:NU(NCr)-Foxn1nu -Homozygous nude mice (SW48 xenografts cells)[1] Dosage: 120 mg/kg Administration: P.o.; daily for 22 days Result: Inhibited tumor growth. |
| References |
| Molecular Formula | C31H30ClF3N8O5 |
|---|---|
| Molecular Weight | 687.07 |