2477651-10-6

2477651-10-6 structure

Name: USP8-IN-3
Chemical Name: USP8-IN-3
CAS Number: 2477651-10-6
Molecular Formula: C₁₈H₁₈F₃N₅O₂S
Molecular Weight: 425.43
Catalog: Signaling Pathways Cell Cycle/DNA Damage Deubiquitinase
Create Date: 2023-05-20 19:26:37
Modify Date: 2024-01-17 23:02:36
USP8-IN-3 (Compd U51) is a deubiquitinase USP8 inhibitor with an IC50 value of 4.0 μM. USP8-IN-3 also inhibits the proliferation of GH3 and H1957 cells with GI50s of 37.03 μM and 6.01 μM, respectively[1].

Name	USP8-IN-3

Description	USP8-IN-3 (Compd U51) is a deubiquitinase USP8 inhibitor with an IC50 value of 4.0 μM. USP8-IN-3 also inhibits the proliferation of GH3 and H1957 cells with GI50s of 37.03 μM and 6.01 μM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase
Target	USP8:4.0 μM (IC50)
In Vitro	USP8-IN-3 (6.25-100 μM; 15 min) 抑制 USP8 对二聚泛素的剪切活性[1]。 Western Blot Analysis[1] Cell Line: / Concentration: 6.25 μM, 12.5 μM, 25 μM, 50 μM, and 100 μM Incubation Time: 15 min; added Di-Ub substrate for another 1 h Result: Decreased the cleaved diubiquitin level.
References	[1]. Li zhiyun, et al. Preparing method and application of USP8 inhibitor: China, CN111138358 A. 2020-05-12.

Molecular Formula	C₁₈H₁₈F₃N₅O₂S
Molecular Weight	425.43