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210980-68-0

210980-68-0 structure
210980-68-0 structure
  • Name: Dehydrosimvastatin
  • Chemical Name: [(1S,3R,7S,8S,8aR)-3,7-dimethyl-8-[2-[(2R)-6-oxo-2,3-dihydropyran-2-yl]ethyl]-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
  • CAS Number: 210980-68-0
  • Molecular Formula: C25H36O4
  • Molecular Weight: 400.551
  • Catalog: Research Areas Others
  • Create Date: 2018-06-25 11:36:33
  • Modify Date: 2024-01-09 20:10:41
  • Anhydrosimvastatin (Impurity C) is an impurity of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase[1].

Name [(1S,3R,7S,8S,8aR)-3,7-dimethyl-8-[2-[(2R)-6-oxo-2,3-dihydropyran-2-yl]ethyl]-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
Synonyms Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-8-[2-[(2R)-3,6-dihydro-6-oxo-2H-pyran-2-yl]ethyl]-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-1-naphthalenyl ester
anhydrosimvastatin
(1S,3R,7S,8S,8aR)-3,7-Dimethyl-8-{2-[(2R)-6-oxo-3,6-dihydro-2H-pyran-2-yl]ethyl}-1,2,3,7,8,8a-hexahydro-1-naphthalenyl 2,2-dimethylbutanoate
Dehydrosimvastatin
Dehydro Simvastatin
Anhydro-simvastatin
Simvastatin EP Impurity C
Dehydrosimvastatin
Simvastatin Impurity 3
Description Anhydrosimvastatin (Impurity C) is an impurity of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase[1].
Related Catalog
References

[1]. IOANA DRĂGHICI, et al. DEVELOPMENT OF A NEW LC METHOD FOR THE IDENTIFICATION, SEPARATION AND ASSAY OF SIMVASTATIN AND ITS IMPURITIES. FARMACIA, 2013, Vol. 61, 2.

Density 1.1±0.1 g/cm3
Boiling Point 536.8±50.0 °C at 760 mmHg
Molecular Formula C25H36O4
Molecular Weight 400.551
Flash Point 265.6±28.5 °C
Exact Mass 400.261353
PSA 52.60000
LogP 5.81
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.529
Hazard Codes Xi
RIDADR NONH for all modes of transport

~4%

210980-68-0 structure

210980-68-0

Literature: WO2005/40107 A2, ; Page/Page column 31-32; 61-62 ;
Detail
Literature: WO2005/40107 A2, ; Page/Page column 51-53 ;

~%

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210980-68-0

Literature: WO2005/40107 A2, ; Page/Page column 73-74 ;

~12%

210980-68-0 structure

210980-68-0

Detail
Literature: WO2005/40107 A2, ; Page/Page column 45; 83 ;

~0%

210980-68-0 structure

210980-68-0

Detail
Literature: WO2005/40107 A2, ; Page/Page column 41-43; 80-82 ;

~%

210980-68-0 structure

210980-68-0

Literature: WO2005/40107 A2, ; Page/Page column 75-76 ;