145576-25-6

145576-25-6 structure

Name: Acetyl simvastatin
Chemical Name: [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-acetyloxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
CAS Number: 145576-25-6
Molecular Formula: C₂₇H₄₀O₆
Molecular Weight: 460.603
Catalog: Research Areas Others
Create Date: 2018-03-29 08:00:00
Modify Date: 2024-01-04 19:17:47
4-Acetylsimvastatin is an acetylated simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM[1].

Name	[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-acetyloxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
Synonyms	(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-Acetoxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl 2,2-dimethylbutanoate Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-(acetyloxy)tetrahydro-6-oxo-2H-pyran-2-yl]ethyl]-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-1-naphthalenyl ester 4'-Acetyl Simvastatin Acetyl simvastatin Simvastatin EP Impurity B Simvastatin Impurity 2

Description	4-Acetylsimvastatin is an acetylated simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Brian Morgan, ey al. Methods for Making Simvastatin and Intermediates. US20110059493A1.

145576-24-5

29138-64-5

~97%

210980-68-0

850920-00-2

Detail

Literature: WO2005/40107 A2, ; Page/Page column 41-43; 80-82 ;

145576-24-5

29138-64-5

~97%

145576-25-6

Literature: DIVERSA CORPORATION Patent: WO2005/40107 A2, 2005 ; Location in patent: Page/Page column 31; 61 ;

145576-24-5

850920-00-2

81189-92-6

29138-64-5

151006-15-4

Detail

Literature: WO2005/40107 A2, ; Page/Page column 51-53 ;

145576-24-5

5856-77-9

~43%

210980-68-0

145576-25-6

Detail

Literature: WO2005/40107 A2, ; Page/Page column 45; 83 ;

145576-24-5

5856-77-9

~85%

145576-25-6

Literature: DIVERSA CORPORATION Patent: WO2005/40107 A2, 2005 ; Location in patent: Page/Page column 66; 68 ;