108334-68-5

108334-68-5 structure

Name: Syntide 2 trifluoroacetate salt
Chemical Name: syntide 2
CAS Number: 108334-68-5
Molecular Formula: C₆₈H₁₂₂N₂₀O₁₈
Molecular Weight: 1507.82000
Catalog: Peptides
Create Date: 2018-12-28 18:20:50
Modify Date: 2024-01-14 13:53:17
Syntide 2 is recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII) with a Ki of 12 μM.

Name	syntide 2
Synonyms	CALMODULIN-DEPENDENT PROTEIN KINASE SUBSTRATE CA2+/CALMODULIN KINASE II SUBSTRATE H-PRO-LEU-ALA-ARG-THR-LEU-SER-VAL-ALA-GLY-LEU-PRO-GLY-LYS-LYS-OH PRO-LEU-ALA-ARG-THR-LEU-SER-VAL-ALA-GLY-LEU-PRO-GLY-LYS-LYS PRO-LEU-ALA-ARG-THR-LEU-SER-VAL-GLY-LEU-PRO-GLY-LYS-LYS SYNTIDE-2 [PLARTLSVAGLPGKK] Syntide2calmodulin-dependentproteinkinase PLARTLSVAGLPGKK

Description	Syntide 2 is recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII) with a Ki of 12 μM.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> CaMK Research Areas >> Neurological Disease Peptides
Target	Km: 12 μM (CaMKII)[1]
In Vitro	The sequence of syntide-2 (pro-leu-ala-arg-thr-leu-ser-val-ala-gly-leu-pro-gly-lys-lys) is homologous to phosphorylation site 2 in glycogen synthase. The relative Vmax/Km ratios of the known Ca2+-dependent protein kinases for syntide-2 are determined to be as follows: protein kinase II, 100; protein kinase C, 22; phosphorylase kinase, 2; myosin light chain kinase, 0.005[1].
References	[1]. Hashimoto Y, et al. Calcium . calmodulin-dependent protein kinase II and calcium . phospholipid-dependent protein kinase activities in rat tissues assayed with a synthetic peptide. Arch Biochem Biophys. 1987 Feb 1;252(2):418-25.