596104-94-8

596104-94-8 structure

Name: 11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID
Chemical Name: 7-(2-oct-2-enylidene-3-oxocyclopentyl)hept-5-enoic acid
CAS Number: 596104-94-8
Molecular Formula: C₂₀H₃₀O₃
Molecular Weight: 318.450
Catalog: Signaling Pathways Cell Cycle/DNA Damage PPAR
Create Date: 2017-12-09 22:38:45
Modify Date: 2024-01-19 12:18:59
CAY10410 (11-Oxo-prosta-5Z), a 15d-PGJ2 analog, is a potent PPARγ agonist. CAY10410 has the ability to activate PPARγ in human B cells without killing B lymphocytes[1].

Name	7-(2-oct-2-enylidene-3-oxocyclopentyl)hept-5-enoic acid
Synonyms	(5Z,12E,14Z)-11-Oxoprosta-5,12,14-trien-1-oic acid Prosta-5,12,14-trien-1-oic acid, 11-oxo-, (5Z,12E,14Z)-

Description	CAY10410 (11-Oxo-prosta-5Z), a 15d-PGJ2 analog, is a potent PPARγ agonist. CAY10410 has the ability to activate PPARγ in human B cells without killing B lymphocytes[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR
Target	PPARγ
In Vitro	Cay10410 (11-Oxo-prosta-5Z; 1 μM; 24 h) 激活 PPRE-LUC 活性，该激活被 B细胞中的 PPARγ DN 抑制[1]。 Cay10410 (0-25 μM; 48 h) 对 Ramos 细胞或正常人 B 细胞均无抑制作用，即使剂量高达 25 μM[1]。
References	[1]. Ray DM, et, al. The peroxisome proliferator-activated receptor gamma (PPARgamma) ligands 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone induce human B lymphocyte and B cell lymphoma apoptosis by PPARgamma-independent mechanisms. J Immunol. 2006 Oct 15;177(8):5068-76.