83824-29-7

83824-29-7 structure

Name: CH2COOH-PEG6-CH2COOH
Chemical Name: 2-[2-[2-[2-[2-[2-[2-(carboxymethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
CAS Number: 83824-29-7
Molecular Formula: C₁₆H₃₀O₁₁
Molecular Weight: 398.40300
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-21 20:59:39
Modify Date: 2024-01-10 13:02:41
CH2COOH-PEG6-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[2-[2-[2-[2-[2-(carboxymethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
Synonyms	3,6,9,12,15,18,21-Heptaoxatricosanedioic acid 3,6,9,12,15,18,21-heptaoxatricosane-1,23-dioic acid

Description	CH2COOH-PEG6-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula	C₁₆H₃₀O₁₁
Molecular Weight	398.40300
Exact Mass	398.17900
PSA	139.21000

Hazard Codes	Xi

211746-80-4

~97%

83824-29-7

Literature: Wittmann, Valentin; Takayama, Shuichi; Gong, Ke Wei; Weitz-Schmidt, Gabriele; Wong, Chi-Huey Journal of Organic Chemistry, 1998 , vol. 63, # 15 p. 5137 - 5143

2615-15-8

83824-29-7

Literature: Wittmann, Valentin; Takayama, Shuichi; Gong, Ke Wei; Weitz-Schmidt, Gabriele; Wong, Chi-Huey Journal of Organic Chemistry, 1998 , vol. 63, # 15 p. 5137 - 5143

Precursor 1
2615-15-8
DownStream 1
211746-85-9

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