CH2COOH-PEG6-CH2COOH

Modify Date: 2024-01-10 13:02:41

CH2COOH-PEG6-CH2COOH structure	Common Name	CH2COOH-PEG6-CH2COOH
	CAS Number	83824-29-7	Molecular Weight	398.40300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₃₀O₁₁	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CH2COOH-PEG6-CH2COOH

CH2COOH-PEG6-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[2-[2-[2-[2-[2-(carboxymethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
Synonym	More Synonyms

Description	CH2COOH-PEG6-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula	C₁₆H₃₀O₁₁
Molecular Weight	398.40300
Exact Mass	398.17900
PSA	139.21000

Hazard Codes	Xi

N/A

CAS#:211746-80-4

~97%

CH2COOH-PEG6-CH2COOH

CAS#:83824-29-7

Literature: Wittmann, Valentin; Takayama, Shuichi; Gong, Ke Wei; Weitz-Schmidt, Gabriele; Wong, Chi-Huey Journal of Organic Chemistry, 1998 , vol. 63, # 15 p. 5137 - 5143

hexaethyleneglycol

CAS#:2615-15-8

CH2COOH-PEG6-CH2COOH

CAS#:83824-29-7

Literature: Wittmann, Valentin; Takayama, Shuichi; Gong, Ke Wei; Weitz-Schmidt, Gabriele; Wong, Chi-Huey Journal of Organic Chemistry, 1998 , vol. 63, # 15 p. 5137 - 5143