2309-07-1

2309-07-1 structure

Name: Methyl 4-hydroxy-3-methoxycinnamate
Chemical Name: trans-methylferulate
CAS Number: 2309-07-1
Molecular Formula: C₁₁H₁₂O₄
Molecular Weight: 208.21
Catalog: Biochemical Plant extracts
Create Date: 2018-07-23 20:01:09
Modify Date: 2024-01-02 17:09:30
Ferulic acid methyl ester (Methyl ferulate) is a derivative of ferulic acid, isolated from Stemona tuberosa, with anti-inflammatory and antioxidant properties[1][2]. Ferulic acid methyl ester is a cell membrane and brain permeable compound, shows free radical scavenging ability, used in the research of neurodegenerative disorders[1]. Ferulic acid methyl ester inhibits COX-2 expression, blocks p-p38 and p-JNK in primary bone marrow derived-macrophages[2].

Name	trans-methylferulate
Synonyms	Ferulic acid methyl ester Methyl (2E)-3-(4-hydroxy-3-methoxyphenyl)acrylate ferulic acid amide Ferulasaeure-amid 2-Propenoic acid, 3- (4-hydroxy-3-methoxyphenyl)-, methyl ester Ferulamid Methyl ferulate methyl (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate 4-Hydroxy-3-methoxy-zimtsaeure-amid Methyl 4-hydroxy-3-methoxycinnamate 4-Oxy-3-methoxy-zimtsaeure-amid Ferulamide 4-hydroxy-3-methoxy-cinnamic acid amide 4-Hydroxy-3-Methoxycinnamide methyl (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate MFCD00017208 methyl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate 2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, methyl ester, (2E)- 2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, methyl ester (9CI) CINNAMIC ACID,4-HYDROXY-3-METHOXY-,METHYL ESTER CINNAMAMIDE,4-HYDROXY-3-METHOXY methyl 3-(4-hydroxy-3-methoxyphenyl)acrylate Ferulic amide feruloylamide 3-(4-Hydroxy-3-methoxyphenyl)-2-propenamide

Description	Ferulic acid methyl ester (Methyl ferulate) is a derivative of ferulic acid, isolated from Stemona tuberosa, with anti-inflammatory and antioxidant properties[1][2]. Ferulic acid methyl ester is a cell membrane and brain permeable compound, shows free radical scavenging ability, used in the research of neurodegenerative disorders[1]. Ferulic acid methyl ester inhibits COX-2 expression, blocks p-p38 and p-JNK in primary bone marrow derived-macrophages[2].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	p38
In Vitro	Ferulic acid methyl ester (Methyl ferulate; 5, 10, 25 µg/mL) suppresses TNFα, IL6, IFNγ but not IL10, inhibits NO generation at 10 and 25 µg/mL, in primary bone marrow derived-macrophages (BMDMs)[2]. Ferulic acid methyl ester (25 µg/mL) inhibits COX-2 expression, blocks p-p38 and p-JNK[2].
References	[1]. Sultana R. Ferulic acid ethyl ester as a potential therapy in neurodegenerative disorders. Biochim Biophys Acta. 2012 May;1822(5):748-52. [2]. Phuong NT, et al. Anti-inflammatory activity of methyl ferulate isolated from Stemona tuberosa Lour. Asian Pac J Trop Med. 2014 Sep;7S1:S327-31.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 25,187,1987

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%