924296-19-5
924296-19-5 structure
- Name: DUBs-IN-2
- Chemical Name: 9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-(ethoxyimino)
- CAS Number: 924296-19-5
- Molecular Formula: C15H9N5O
- Molecular Weight: 275.26500
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Deubiquitinase
- Create Date: 2017-03-25 22:54:42
- Modify Date: 2024-01-12 10:11:36
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DUBs-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8.
| Name | 9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-(ethoxyimino) |
|---|---|
| Synonyms |
9-Ethoxyimino-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
DUBs-IN-2 |
| Description | DUBs-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.28 μM (USP8)[1] |
| In Vitro | DUBs-IN-2 (compound 22 e) is a potent USP8 inhibitor with an IC50 of 0.28 μM, and has no effect on USP7, with an IC50 of >100 μM. DUBs-IN-2 inhibits the viability of HCT116 colon cell line and PC-3 prostate cancer cell line with IC50 values of 0.5-1.5 μM[1]. |
| References |
| Density | 1.36±0.1 g/cm3 (20 °C, 760 mmHg) |
|---|---|
| Boiling Point | 555.7±60.0 °C (760 mmHg) |
| Molecular Formula | C15H9N5O |
| Molecular Weight | 275.26500 |
| Exact Mass | 275.08100 |
| PSA | 94.95000 |
| LogP | 1.98926 |