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756525-95-8

756525-95-8 structure
756525-95-8 structure
  • Name: NH2-PEG2-C2-Boc
  • Chemical Name: tert-butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate
  • CAS Number: 756525-95-8
  • Molecular Formula: C11H23NO4
  • Molecular Weight: 233.305
  • Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
  • Create Date: 2019-01-05 19:09:47
  • Modify Date: 2024-01-02 13:27:56
  • NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

Name tert-butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate
Synonyms 2-Methyl-2-propanyl 3-[2-(2-aminoethoxy)ethoxy]propanoate
Propanoic acid, 3-[2-(2-aminoethoxy)ethoxy]-, 1,1-dimethylethyl ester
tert-butyl 3-[2-(2-aminoethoxy)ethoxy]propanoate
tert-butyl 9-AMino-4,7-dioxanonanoate
Description NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Related Catalog
Target

PEGs

Alkyl/ether

Non-cleavable

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
References

[1]. Han X, et al. Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. J Med Chem. 2019 Jan 24;62(2):941-964.

[2]. Joshua D. Thomas, et al. Pyrrolobenzodiazepine antibody conjugates. WO2019126691A1.

Density 1.0±0.1 g/cm3
Boiling Point 313.7±22.0 °C at 760 mmHg
Molecular Formula C11H23NO4
Molecular Weight 233.305
Flash Point 103.3±18.7 °C
Exact Mass 233.162704
PSA 70.78000
LogP 0.48
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.450