Name | tert-butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate |
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Synonyms |
2-Methyl-2-propanyl 3-[2-(2-aminoethoxy)ethoxy]propanoate
Propanoic acid, 3-[2-(2-aminoethoxy)ethoxy]-, 1,1-dimethylethyl ester tert-butyl 3-[2-(2-aminoethoxy)ethoxy]propanoate tert-butyl 9-AMino-4,7-dioxanonanoate |
Description | NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
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Related Catalog | |
Target |
PEGs Alkyl/ether Non-cleavable |
In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
References |
[2]. Joshua D. Thomas, et al. Pyrrolobenzodiazepine antibody conjugates. WO2019126691A1. |
Density | 1.0±0.1 g/cm3 |
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Boiling Point | 313.7±22.0 °C at 760 mmHg |
Molecular Formula | C11H23NO4 |
Molecular Weight | 233.305 |
Flash Point | 103.3±18.7 °C |
Exact Mass | 233.162704 |
PSA | 70.78000 |
LogP | 0.48 |
Vapour Pressure | 0.0±0.7 mmHg at 25°C |
Index of Refraction | 1.450 |