NH2-PEG2-C2-Boc
Modify Date: 2024-01-02 13:27:56
NH2-PEG2-C2-Boc structure
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Common Name | NH2-PEG2-C2-Boc | ||
|---|---|---|---|---|
| CAS Number | 756525-95-8 | Molecular Weight | 233.305 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 313.7±22.0 °C at 760 mmHg | |
| Molecular Formula | C11H23NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 103.3±18.7 °C | |
Use of NH2-PEG2-C2-BocNH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
| Name | tert-butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate |
|---|---|
| Synonym | More Synonyms |
| Description | NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
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| Related Catalog | |
| Target |
PEGs Alkyl/ether Non-cleavable |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
| References |
[2]. Joshua D. Thomas, et al. Pyrrolobenzodiazepine antibody conjugates. WO2019126691A1. |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 313.7±22.0 °C at 760 mmHg |
| Molecular Formula | C11H23NO4 |
| Molecular Weight | 233.305 |
| Flash Point | 103.3±18.7 °C |
| Exact Mass | 233.162704 |
| PSA | 70.78000 |
| LogP | 0.48 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.450 |
| 2-Methyl-2-propanyl 3-[2-(2-aminoethoxy)ethoxy]propanoate |
| Propanoic acid, 3-[2-(2-aminoethoxy)ethoxy]-, 1,1-dimethylethyl ester |
| tert-butyl 3-[2-(2-aminoethoxy)ethoxy]propanoate |
| tert-butyl 9-AMino-4,7-dioxanonanoate |