GW 833972A

Modify Date: 2024-09-16 19:52:01

GW 833972A Structure
GW 833972A structure
Common Name GW 833972A
CAS Number 1092502-33-4 Molecular Weight 444.23800
Density N/A Boiling Point N/A
Molecular Formula C18H14Cl2F3N5O Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS06
GHS06
Signal Word Danger

 Use of GW 833972A


GW 833972A is a selective CB2 receptor agonist. GW 833972A inhibits induced nerve depolarization and citric acid-induced cough in animal models[1].

 Names

Name 2-(3-chloroanilino)-N-(pyridin-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide,hydrochloride
Synonym More Synonyms

 GW 833972A Biological Activity

Description GW 833972A is a selective CB2 receptor agonist. GW 833972A inhibits induced nerve depolarization and citric acid-induced cough in animal models[1].
Related Catalog
Target

hCB2-R:7.3 (pEC50)

rat CB2-R:7.5 (pEC50)

In Vitro GW 833972A (0.3-300 μM; 10 min) 抑制辣椒素诱导的人和豚鼠去极化,还抑制前列腺素 E(2) 和高渗盐水诱导的豚鼠离体迷走神经去极化[1]。
In Vivo GW 833972A (30 mg/kg, 2 mL/kg;腹腔注射; 单次剂量, 试验开始前 30 min 注射) 能够抑制柠檬酸诱导的有意识豚鼠的咳嗽症状。它还抑制辣椒素引起的主支气管血浆蛋白渗出现象[1]。
References

[1]. Belvisi MG, et al. Inhibitory activity of the novel CB2 receptor agonist, GW833972A, on guinea-pig and human sensory nerve function in the airways. Br J Pharmacol. 2008 Oct;155(4):547-57.  

 Chemical & Physical Properties

Molecular Formula C18H14Cl2F3N5O
Molecular Weight 444.23800
Exact Mass 443.05300
PSA 83.29000
LogP 5.66720
Storage condition 2-8°C

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301-H315-H319-H335-H413
Precautionary Statements P261-P301 + P310-P305 + P351 + P338
Hazard Codes T+
Risk Phrases 25-36/37/38
Safety Phrases 26-45
RIDADR UN 2811 6.1 / PGIII

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 Synonyms

2-[(3-chlorophenyl)amino]-N-(4-pyridinylmethyl)-4-(trifluoromethyl)-5-Pyrimidinecarboxamide hydrochloride