GW 833972A structure
|
Common Name | GW 833972A | ||
---|---|---|---|---|
CAS Number | 1092502-33-4 | Molecular Weight | 444.23800 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C18H14Cl2F3N5O | Melting Point | N/A | |
MSDS | Chinese USA | Flash Point | N/A | |
Symbol |
GHS06 |
Signal Word | Danger |
Use of GW 833972AGW 833972A is a selective CB2 receptor agonist. GW 833972A inhibits induced nerve depolarization and citric acid-induced cough in animal models[1]. |
Name | 2-(3-chloroanilino)-N-(pyridin-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide,hydrochloride |
---|---|
Synonym | More Synonyms |
Description | GW 833972A is a selective CB2 receptor agonist. GW 833972A inhibits induced nerve depolarization and citric acid-induced cough in animal models[1]. |
---|---|
Related Catalog | |
Target |
hCB2-R:7.3 (pEC50) rat CB2-R:7.5 (pEC50) |
In Vitro | GW 833972A (0.3-300 μM; 10 min) 抑制辣椒素诱导的人和豚鼠去极化,还抑制前列腺素 E(2) 和高渗盐水诱导的豚鼠离体迷走神经去极化[1]。 |
In Vivo | GW 833972A (30 mg/kg, 2 mL/kg;腹腔注射; 单次剂量, 试验开始前 30 min 注射) 能够抑制柠檬酸诱导的有意识豚鼠的咳嗽症状。它还抑制辣椒素引起的主支气管血浆蛋白渗出现象[1]。 |
References |
Molecular Formula | C18H14Cl2F3N5O |
---|---|
Molecular Weight | 444.23800 |
Exact Mass | 443.05300 |
PSA | 83.29000 |
LogP | 5.66720 |
Storage condition | 2-8°C |
Symbol |
GHS06 |
---|---|
Signal Word | Danger |
Hazard Statements | H301-H315-H319-H335-H413 |
Precautionary Statements | P261-P301 + P310-P305 + P351 + P338 |
Hazard Codes | T+ |
Risk Phrases | 25-36/37/38 |
Safety Phrases | 26-45 |
RIDADR | UN 2811 6.1 / PGIII |
Virological response to short-course maraviroc monotherapy does not predict viral tropism in HIV-1-infected treatment-naive patients.
J. Antimicrob. Chemother. , (2014) We aimed to evaluate whether virological response to a short course of maraviroc monotherapy could predict HIV-1 tropism.A clinical trial was performed in HIV-1 treatment-naive patients infected with ... |
|
Epidemiology of genital herpes simplex virus type 1 and 2 infections in southwestern Finland during a 10-year period (2003-2012).
Sex. Transm. Dis. 41(4) , 268-71, (2014) The objective of this study was to analyze the proportion of herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) in genital infections during a 10-year period (2003-2012) among outpatients of a clini... |
|
PlayerLoad™: reliability, convergent validity, and influence of unit position during treadmill running.
Int. J. Sports Physiol. Perform. , (2014) The study aimed to establish the test-retest reliability and convergent validity of PlayerLoad™ (triaxial-accelerometer data) during a standardized bout of treadmill running.Forty-four team-sport play... |
2-[(3-chlorophenyl)amino]-N-(4-pyridinylmethyl)-4-(trifluoromethyl)-5-Pyrimidinecarboxamide hydrochloride |