DHODH-IN-3

Modify Date: 2024-04-05 20:24:05

DHODH-IN-3 Structure
DHODH-IN-3 structure
Common Name DHODH-IN-3
CAS Number 1148126-04-8 Molecular Weight 312.75
Density N/A Boiling Point N/A
Molecular Formula C17H13ClN2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DHODH-IN-3


DHODH-IN-3 (compound 3) is a potent inhibitor of Human Dihydroorotate Dehydrogenases (HsDHODH) with an IC50 value of 261 nM. DHODH-IN-3 binds to the the ubiquinone binding cavities in DHODH with a Kiapp of 32 nM. DHODH-IN-3 has the potential for malaria treatment[1].

 Names

Name DHODH-IN-3

 DHODH-IN-3 Biological Activity

Description DHODH-IN-3 (compound 3) is a potent inhibitor of Human Dihydroorotate Dehydrogenases (HsDHODH) with an IC50 value of 261 nM. DHODH-IN-3 binds to the the ubiquinone binding cavities in DHODH with a Kiapp of 32 nM. DHODH-IN-3 has the potential for malaria treatment[1].
Related Catalog
Target

IC50: 261 nM (HsDHODH)[1]

In Vitro DHODH-IN-3 (compound 3) show good inhibitory effects on HsDHODH with IC50 value of 261 nM. It binds to HsDHODH with a Kiapp value of 32 nM[1].
References

[1]. Davies M, et al. Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases.J Med Chem. 2009 May 14;52(9):2683-93.

 Chemical & Physical Properties

Molecular Formula C17H13ClN2O2
Molecular Weight 312.75
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