TC JL 37

Modify Date: 2024-04-02 13:00:34

TC JL 37 Structure
TC JL 37 structure
Common Name TC JL 37
CAS Number 1258294-34-6 Molecular Weight 376.74
Density N/A Boiling Point N/A
Molecular Formula C17H11ClF2N4O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TC JL 37


TCJL37 is a potent, selective, and orally bioavailable TYK2 inhibitor with a Ki of 1.6 nM. TCJL37 can be used for the research of inflammatory bowel diseases (IBD)[1].

 Names

Name TCJL37

 TC JL 37 Biological Activity

Description TCJL37 is a potent, selective, and orally bioavailable TYK2 inhibitor with a Ki of 1.6 nM. TCJL37 can be used for the research of inflammatory bowel diseases (IBD)[1].
Related Catalog
Target

Tyk2:1.6 nM (Ki)

In Vitro In cell-based assays, TCJL37 (Compound 37) shows IL-12 pSTAT4 EC50 of 224 nM. TCJL37 shows EC50s of 168 nM and 737 nM In human peripheral blood mononuclear cells (PBMC) and human whole blood assay, respectively[1].
In Vivo TCJL37 exhibits excellent oral exposure in CD-1 mice following oral administration (100 mg/kg). TCJL37 exhibits low clearance (1.0 mL/min/kg) in rat[1].
References

[1]. Jun Liang, et al. Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors. J Med Chem. 2013 Jun 13;56(11):4521-36.

 Chemical & Physical Properties

Molecular Formula C17H11ClF2N4O2
Molecular Weight 376.74
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