ML-243

Modify Date: 2024-01-09 12:28:36

ML-243 structure	Common Name	ML-243
	CAS Number	1426576-80-8	Molecular Weight	260.355
	Density	1.2±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₆N₂OS	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of ML-243

ML243 is a selective small-molecule inhibitor of breast cancer stem cells. ML243 has 32-fold greater selective inhibition in the breast CSC-like cell line HMLE_shECad than the control cell line HMLE_shGFP[1].

Name	(2E)-N-(4,5-Dihydro-1,3-thiazol-2-yl)-3-(4-ethylphenyl)acrylamide
Synonym	More Synonyms

Description	ML243 is a selective small-molecule inhibitor of breast cancer stem cells. ML243 has 32-fold greater selective inhibition in the breast CSC-like cell line HMLE_shECad than the control cell line HMLE_shGFP[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	Breast CSCs[1]
References	[1]. Carmody L, et al. Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells - Probe 3. 2011 Sep 28 [updated 2013 Mar 7].

Density	1.2±0.1 g/cm3
Molecular Formula	C₁₄H₁₆N₂OS
Molecular Weight	260.355
Exact Mass	260.098328
PSA	70.25000
LogP	2.65
Index of Refraction	1.608

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
RIDADR	NONH for all modes of transport

Aminothiazoline

CAS#:1779-81-3

(E)-3-(4-Ethylp...

CAS#:120680-98-0

~40%

ML-243

CAS#:1426576-80-8

Literature: THE BROAD INSTITUTE, INC.; GERMAIN, Andrew; MUNOZ, Benito; LEWIS, Timothy, A.; TING, Amal; YOUNGSAYE, Willmen; NAG, Partha, P.; DOCKENDORFF, Christopher; FERNANDEZ, Cristina, Victoria; DONCKELE, Etienne; MORGAN, Barbara; SKODA, Erin, M.; SHU, Byubg-Chul Patent: WO2013/32907 A1, 2013 ; Location in patent: Page/Page column 54 ;

(2E)-N-(4,5-Dihydro-1,3-thiazol-2-yl)-3-(4-ethylphenyl)acrylamide

2-Propenamide, N-(4,5-dihydro-2-thiazolyl)-3-(4-ethylphenyl)-, (2E)-

Streptomyces metabolite 2880 II

2880-II