Lauric acid

Modify Date: 2024-01-02 12:11:17

Lauric acid Structure
Lauric acid structure
 Common Name Lauric acid
CAS Number 143-07-7 Molecular Weight 200.318
Density 0.9±0.1 g/cm3 Boiling Point 296.1±3.0 °C at 760 mmHg
Molecular Formula C12H24O2 Melting Point 44-46 °C(lit.)
MSDS Chinese USA Flash Point 134.1±11.9 °C
Symbol GHS05
GHS05		 Signal Word Danger

 Use of Lauric acid


Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

 Names

Name dodecanoic acid
Synonym More Synonyms

 Lauric acid Biological Activity

Description Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Nakatsuji T, et al. Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris. J Invest Dermatol. 2009 Oct;129(10):2480-8.

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 296.1±3.0 °C at 760 mmHg
Melting Point 44-46 °C(lit.)
Molecular Formula C12H24O2
Molecular Weight 200.318
Flash Point 134.1±11.9 °C
Exact Mass 200.177628
PSA 37.30000
LogP 5.03
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.448
Stability Stable. Combustible. Incompatible with bases, oxidizing agents, reducing agents.
Water Solubility insoluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OE9800000
CHEMICAL NAME :
Lauric acid
CAS REGISTRY NUMBER :
143-07-7
BEILSTEIN REFERENCE NO. :
1099477
LAST UPDATED :
199701
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C12-H24-O2
MOLECULAR WEIGHT :
200.36
WISWESSER LINE NOTATION :
QV11

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
12 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
131 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
333 gm/kg/13W-C
TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - fluid intake
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
108 gm/kg/15W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Tumorigenic - active as anti-cancer agent

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Yeast - Saccharomyces cerevisiae
DOSE/DURATION :
10 mg/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 294,263,1981 *** REVIEWS *** TOXICOLOGY REVIEW AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,100,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84696 No. of Facilities: 1256 (estimated) No. of Industries: 14 No. of Occupations: 34 No. of Employees: 14960 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84696 No. of Facilities: 4690 (estimated) No. of Industries: 51 No. of Occupations: 50 No. of Employees: 77970 (estimated) No. of Female Employees: 17300 (estimated)

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H318
Precautionary Statements P280-P305 + P351 + P338 + P310
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi:Irritant
Risk Phrases R36/38
Safety Phrases S37/39-S26
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS OE9800000
HS Code 2916399090

 Synthetic Route

 Customs

HS Code 2915900090
Summary 2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

 Articles157

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Appl. Microbiol. Biotechnol. 99(5) , 2291-304, (2015)

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Researchers have formed peptide bonds under a variety of presumed prebiotic conditions. Here it is proposed that these same conditions would have also formed amide bonds between fatty acids and amino ...

 Synonyms

EINECS 205-582-1
Lauric acid
MFCD00002736
Dodecanoic Acid
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