AZ Dyrk1B 33

Modify Date: 2024-01-10 13:20:37

Use of AZ Dyrk1B 33

AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor, with an IC50 of 7 nM[1].

Name	AZ-Dyrk1B-33

Description	AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor, with an IC50 of 7 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK Research Areas >> Metabolic Disease
Target	IC50: 7 nM (Dyrk1B)[1]
In Vitro	AZ-Dyrk1B-33 shows inhibition of phosphorylation of Dyrk pS421 in cells with an IC50 of 0.192 μM[1]. AZ-Dyrk1B-33 shows no effect in sensitization[1].
References	[1]. Kettle JG, et al. Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. J Med Chem. 2015 Mar 26;58(6):2834-44.

Molecular Formula	C₁₉H₁₆N₄
Molecular Weight	300.36

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Price: ￥1650/5 mg

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