Amino-Tri-(carboxyethoxymethyl)-methane
Modify Date: 2024-01-03 10:23:27
Amino-Tri-(carboxyethoxymethyl)-methane structure
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Common Name | Amino-Tri-(carboxyethoxymethyl)-methane | ||
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| CAS Number | 174362-95-9 | Molecular Weight | 337.32 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H23NO9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Amino-Tri-(carboxyethoxymethyl)-methaneAmino-Tri-(carboxyethoxymethyl)-methane is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Amino-Tri-(carboxyethoxymethyl)-methan is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. |
| Name | Amino-Tri-(carboxyethoxymethyl)-methane |
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| Description | Amino-Tri-(carboxyethoxymethyl)-methane is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Amino-Tri-(carboxyethoxymethyl)-methan is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. |
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| Related Catalog | |
| Target |
PEGs Cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
[1]. Markus Ribbert, et al. Self coupling recombinant antibody fusion proteins. WO2009013359A2. |
| Molecular Formula | C13H23NO9 |
|---|---|
| Molecular Weight | 337.32 |
| Storage condition | 2-8°C |