Methyltetrazine-PEG4-maleimide

Modify Date: 2024-01-05 10:01:48

Methyltetrazine-PEG4-maleimide Structure
Methyltetrazine-PEG4-maleimide structure
Common Name Methyltetrazine-PEG4-maleimide
CAS Number 1802908-02-6 Molecular Weight 613.662
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C24H30N6O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Methyltetrazine-PEG4-maleimide


Methyltetrazine-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Tetrazine-PEG4-maleimide
Synonym More Synonyms

 Methyltetrazine-PEG4-maleimide Biological Activity

Description Methyltetrazine-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C24H30N6O7
Molecular Weight 613.662
Exact Mass 613.286011
LogP -2.38
Index of Refraction 1.556
Storage condition -20°C

 Safety Information

Hazard Codes Xi
Risk Phrases 36/38
Safety Phrases 26

 Synonyms

Methyltetrazine-PEG4-maleimide
1H-Pyrrole-1-butanamide, 2,5-dihydro-N-[17-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]-15-oxo-3,6,9,12-tetraoxa-16-azaheptadec-1-yl]-2,5-dioxo-
20-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl]-17-oxo-4,7,10,13-tetraoxa-16-azaicosan-1-amide
MFCD28053555
Tetrazine-PEG4-maleimide
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