CM-579
Modify Date: 2024-01-30 19:02:25
CM-579 structure
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Common Name | CM-579 | ||
|---|---|---|---|---|
| CAS Number | 1846570-40-8 | Molecular Weight | 492.65 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H40N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CM-579CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells[1]. |
| Name | CM-579 |
|---|
| Description | CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells[1]. |
|---|---|
| Related Catalog | |
| Target |
DNA Methyltransferase:32 nM (IC50) DNMT1:1.5 nM (Kd) DNMT3A:92 nM (IC50) DNMT3B:1000 nM (IC50) G9a:16 nM (IC50) |
| In Vitro | The Kd of CM-579 for DNMT1 is 1.5 nM, CM-579 also inhibits DNMT3A and DNMT3B, with IC50s of 92 nM and 1000 nM, respectively[1]. |
| References |
| Molecular Formula | C29H40N4O3 |
|---|---|
| Molecular Weight | 492.65 |
| Storage condition | 2-8℃ |