ERK-IN-3

Modify Date: 2024-01-01 18:26:18

ERK-IN-3 structure	Common Name	ERK-IN-3
	CAS Number	2055597-12-9	Molecular Weight	473.93
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₅ClFN₇O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ERK-IN-3

ERK-IN-3 is a potent and oral inhibitor of ERK. ERK-IN-3 inhibits ERK1/2 with low single-digit nM IC50 values. ERK-IN-3 has the potential to be used to study cancers driven by RAS mutations.[1].

Name	ERK-IN-3

Description	ERK-IN-3 is a potent and oral inhibitor of ERK. ERK-IN-3 inhibits ERK1/2 with low single-digit nM IC50 values. ERK-IN-3 has the potential to be used to study cancers driven by RAS mutations.[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	ERK1 ERK2
In Vitro	ERK-IN-3 inhibits the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines[1]. ERK-IN-3 showes single-digit nanomolar antiproliferative activity that is selective for MAPK-pathway dependent cancer cell lines[1].
In Vivo	ERK-IN-3 (daily p.o.) inhibits tumor growth in multiple BRAF and KRAS mutant xenograft models in mice and was well tolerated at efficacious doses[1].
References	[1]. Sanjeeva PR, et, al. Abstract B150: ASN007, a novel oral ERK inhibitor, shows robust antitumor activity in RAS mutant cancer models. Molecular Cancer Therapeutics. 2018 Jan; 17(1).

Molecular Formula	C₂₂H₂₅ClFN₇O₂
Molecular Weight	473.93

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ERK-IN-3
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: ERK-IN-3
Price: $759.0/100mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Get all suppliers and price by the below link:

ERK-IN-3 suppliers

ERK-IN-3 price

ERK-IN-3

Use of ERK-IN-3

Names

ERK-IN-3 Biological Activity

Chemical & Physical Properties