HS 014 TFA

Modify Date: 2024-01-02 09:39:51

HS 014 TFA structure	Common Name	HS 014 TFA
	CAS Number	207678-81-7	Molecular Weight	1563.760
	Density	1.6±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₇₁H₉₄N₂₀O₁₇S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HS 014 TFA

HS014 is a potent and selective melanocortin-4 (MC4) receptor antagonist, with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats[1][2][3].

Name	hs 014
Synonym	More Synonyms

Description	HS014 is a potent and selective melanocortin-4 (MC4) receptor antagonist, with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats[1][2][3].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Melanocortin Receptor
In Vivo	The dose-effect curve of morphine for locomotor activity was shifted downwards in C57Bl/6 mice pretreated with HS014 and in A(y) mice. The dose-effect curve of morphine for antinociception is shifted two- and threefold to the left in C57Bl/6 mice pretreated with HS014 and in A(y) mice, respectively[2]. Pretreatment with HS014 blocks the effect of IL-1beta on food intake and respiratory exchange ratio (RER) at later time points (beyond 8 h post injection), as well as the hypoactivity and increases metabolic rate[4].
References	[1]. Schiöth HB,et al. Discovery of novel melanocortin4 receptor selective MSH analogues. Br J Pharmacol. 1998;124(1):75-82. [2]. Ercil NE, et al. HS014, a selective melanocortin-4 (MC4) receptor antagonist, modulates the behavioral effects of morphine in mice. Psychopharmacology (Berl). 2005;180(2):279-285. [3]. Kask A, et al. Selective antagonist for the melanocortin 4 receptor (HS014) increases food intake in free-feeding rats. Biochem Biophys Res Commun. 1998;245(1):90-93.

Density	1.6±0.1 g/cm3
Molecular Formula	C₇₁H₉₄N₂₀O₁₇S₂
Molecular Weight	1563.760
Exact Mass	1562.654663
PSA	632.30000
LogP	-3.97
Index of Refraction	1.730

Safety Phrases	22-24/25
WGK Germany	3

mc4receptor antagonist

1-{[(4R,10S,13S,16R,19S,22S,25R)-25-Acetamido-13-(3-carbamimidamidopropyl)-22-(2-carboxyethyl)-19-(1H-imidazol-4-ylmethyl)-10-(1H-indol-3-ylmethyl)-16-(2-naphthylmethyl)-6,9,12,15,18,21,24-heptaoxo-1, ;2-dithia-5,8,11,14,17,20,23-heptaazacyclohexacosan-4-yl]carbonyl}-L-prolyl-L-prolyl-L-lysyl-L-α-asparagine

L-α-Asparagine, 1-[[(4R,10S,13S,16R,19S,22S,25R)-25-(acetylamino)-13-[3-[(aminoiminomethyl)amino]propyl]-22-(2-carboxyethyl)-19-(1H-imidazol-4-ylmethyl)-10-(1H-indol-3-ylmethyl)-16-(2-naphthalenyl methyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaazacyclohexacos-4-yl]carbonyl]-L-prolyl-L-prolyl-L-lysyl-

HS014

AC-CYS-GLU-HIS-D-2-NAL-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2

M.W. 1563.77 C71H94N20O17S2