Thalidomide-NH-C6-NH2 TFA

Modify Date: 2024-01-10 20:52:29

Thalidomide-NH-C6-NH2 TFA Structure
Thalidomide-NH-C6-NH2 TFA structure
Common Name Thalidomide-NH-C6-NH2 TFA
CAS Number 2093386-51-5 Molecular Weight 486.44
Density N/A Boiling Point N/A
Molecular Formula C21H25F3N4O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thalidomide-NH-C6-NH2 TFA


Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

 Names

Name Thalidomide-NH-C6-NH2 TFA

 Thalidomide-NH-C6-NH2 TFA Biological Activity

Description Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Related Catalog
In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.

 Chemical & Physical Properties

Molecular Formula C21H25F3N4O6
Molecular Weight 486.44

 Safety Information

Hazard Codes Xi