Thalidomide-NH-C4-NH2 TFA

Modify Date: 2024-01-10 10:05:58

Thalidomide-NH-C4-NH2 TFA Structure
Thalidomide-NH-C4-NH2 TFA structure
Common Name Thalidomide-NH-C4-NH2 TFA
CAS Number 2093387-50-7 Molecular Weight 458.39
Density N/A Boiling Point N/A
Molecular Formula C19H21F3N4O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thalidomide-NH-C4-NH2 TFA


Thalidomide-NH-C4-NH2 TFA (compound 29c) is an E3 ligase ligand-linker conjugate, and incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-NH-C4-NH2 TFA is used in PROTAC BRD2/BRD4 degrader-1 (HY-130612). PROTAC BRD2/BRD4 degrader-1 is a potent and selective BET protein BRD4 and BRD2 degrader[1].

 Names

Name Thalidomide-NH-C4-NH2 TFA
Synonym More Synonyms

 Thalidomide-NH-C4-NH2 TFA Biological Activity

Description Thalidomide-NH-C4-NH2 TFA (compound 29c) is an E3 ligase ligand-linker conjugate, and incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-NH-C4-NH2 TFA is used in PROTAC BRD2/BRD4 degrader-1 (HY-130612). PROTAC BRD2/BRD4 degrader-1 is a potent and selective BET protein BRD4 and BRD2 degrader[1].
Related Catalog
Target

Cereblon

References

[1]. Jiang F, et al. Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies. Bioorg Med Chem. 2020 Jan 1;28(1):115181.

 Chemical & Physical Properties

Molecular Formula C19H21F3N4O6
Molecular Weight 458.39

 Safety Information

Hazard Codes Xi

 Synonyms

MFCD13184969