Thalidomide-NH-C4-NH2 TFA

Modify Date: 2024-01-10 10:05:58

Thalidomide-NH-C4-NH2 TFA structure	Common Name	Thalidomide-NH-C4-NH2 TFA
	CAS Number	2093387-50-7	Molecular Weight	458.39
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₁F₃N₄O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Thalidomide-NH-C4-NH2 TFA

Thalidomide-NH-C4-NH2 TFA (compound 29c) is an E3 ligase ligand-linker conjugate, and incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-NH-C4-NH2 TFA is used in PROTAC BRD2/BRD4 degrader-1 (HY-130612). PROTAC BRD2/BRD4 degrader-1 is a potent and selective BET protein BRD4 and BRD2 degrader[1].

Name	Thalidomide-NH-C4-NH2 TFA
Synonym	More Synonyms

Description	Thalidomide-NH-C4-NH2 TFA (compound 29c) is an E3 ligase ligand-linker conjugate, and incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-NH-C4-NH2 TFA is used in PROTAC BRD2/BRD4 degrader-1 (HY-130612). PROTAC BRD2/BRD4 degrader-1 is a potent and selective BET protein BRD4 and BRD2 degrader[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
References	[1]. Jiang F, et al. Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies. Bioorg Med Chem. 2020 Jan 1;28(1):115181.

Molecular Formula	C₁₉H₂₁F₃N₄O₆
Molecular Weight	458.39

Hazard Codes	Xi

MFCD13184969

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Thalidomide-NH-C4-NH2 TFA
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Purity: 97.0%
Delivery: 10 Day
Contact: Yang
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