N-(Amino-PEG1)-N-bis(PEG2-propargyl)

Modify Date: 2024-01-14 16:34:30

N-(Amino-PEG1)-N-bis(PEG2-propargyl) Structure
N-(Amino-PEG1)-N-bis(PEG2-propargyl) structure
Common Name N-(Amino-PEG1)-N-bis(PEG2-propargyl)
CAS Number 2100306-47-4 Molecular Weight 356.457
Density 1.1±0.1 g/cm3 Boiling Point 443.9±40.0 °C at 760 mmHg
Molecular Formula C18H32N2O5 Melting Point N/A
MSDS N/A Flash Point 222.2±27.3 °C

 Use of N-(Amino-PEG1)-N-bis(PEG2-propargyl)


N-(Amino-PEG1)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 6-{2-[2-(2-Propyn-1-yloxy)ethoxy]ethyl}-3,9,12-trioxa-6-azapentadec-14-yn-1-amine
Synonym More Synonyms

 N-(Amino-PEG1)-N-bis(PEG2-propargyl) Biological Activity

Description N-(Amino-PEG1)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 443.9±40.0 °C at 760 mmHg
Molecular Formula C18H32N2O5
Molecular Weight 356.457
Flash Point 222.2±27.3 °C
Exact Mass 356.231110
LogP -2.60
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.490

 Synonyms

6-{2-[2-(2-Propyn-1-yloxy)ethoxy]ethyl}-3,9,12-trioxa-6-azapentadec-14-yn-1-amine
MFCD30723225
3,9,12-Trioxa-6-azapentadec-14-yn-1-amine, 6-[2-[2-(2-propyn-1-yloxy)ethoxy]ethyl]-
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