THP-PEG4-Pyrrolidine(N-Me)-CH2OH
Modify Date: 2024-01-14 19:19:28
THP-PEG4-Pyrrolidine(N-Me)-CH2OH structure
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Common Name | THP-PEG4-Pyrrolidine(N-Me)-CH2OH | ||
|---|---|---|---|---|
| CAS Number | 2378261-81-3 | Molecular Weight | 391.50 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H37NO7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of THP-PEG4-Pyrrolidine(N-Me)-CH2OHTHP-PEG4-Pyrrolidine(N-Me)-CH2OH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523)[1]. |
| Name | THP-PEG4-Pyrrolidine(N-Me)-CH2OH |
|---|
| Description | THP-PEG4-Pyrrolidine(N-Me)-CH2OH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523)[1]. |
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| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTAC K-Ras Degrader-1 is potent K-Ras degrader based PROTAC, exhibits ≥70% degradation efficacy in SW1573 cells[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
| References |
[1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2. |
| Molecular Formula | C19H37NO7 |
|---|---|
| Molecular Weight | 391.50 |
| Storage condition | -20°C |