PROTAC BRD4 Degrader-6
Modify Date: 2024-01-10 17:51:43
PROTAC BRD4 Degrader-6 structure
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Common Name | PROTAC BRD4 Degrader-6 | ||
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| CAS Number | 2410947-56-5 | Molecular Weight | 926.90 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C43H40F2N10O10S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PROTAC BRD4 Degrader-6PROTAC BRD4 Degrader-6 (compound 32a) is a potent small-molecule BRD4 degrader with IC50 value of 2.7 nM for BRD4 BD1. PROTAC BRD4 Degrader-6 potently degrades BRD4 protein and inhibits the expression of c-Myc. PROTAC BRD4 Degrader-6 inhibits the proliferation of pancreatic cancer cell line BxPC3 and induces apoptosis. PROTAC BRD4 Degrader-6 can be used for human pancreatic cancer research[1]. |
| Name | PROTAC BRD4 Degrader-6 |
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| Description | PROTAC BRD4 Degrader-6 (compound 32a) is a potent small-molecule BRD4 degrader with IC50 value of 2.7 nM for BRD4 BD1. PROTAC BRD4 Degrader-6 potently degrades BRD4 protein and inhibits the expression of c-Myc. PROTAC BRD4 Degrader-6 inhibits the proliferation of pancreatic cancer cell line BxPC3 and induces apoptosis. PROTAC BRD4 Degrader-6 can be used for human pancreatic cancer research[1]. |
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| Related Catalog | |
| Target |
BRD4 BD1:2.7 μM (IC50) Caspase 3 |
| In Vitro | PROTAC BRD4 Degrader-6 (compound 32a) (72 hours; BxPC3 cell) has anti-proliferation activity with IC50 value of 0.165 μM[1]. PROTAC BRD4 Degrader-6 (compound 32a) (1 μM; 48 hours; BxPC3 cell) induces BRD4 protein degradation in a time-dependent manner, which results in the continuous decrease of c-Myc expression[1]. PROTAC BRD4 Degrader-6 (compound 32a) (1 μM; 48 hours; BxPC3 cell) induces the cell cycle arrest and apoptosis[1]. Western Blot Analysis[1] Cell Line: BxPC3 cell Concentration: 1 μM Incubation Time: 48 hours Result: Degraded BRD4 protein in a time-dependent manner and inhibits the expression of c-Myc. Cell Cycle Analysis[1] Cell Line: BxPC3 cell Concentration: 1 μM Incubation Time: 48 hours Result: Increase in G0/G1 and G2/M phase cells, and a decrease of S phase cells. Apoptosis Analysis[1] Cell Line: BxPC3 cell Concentration: 1 μM Incubation Time: 48 hours Result: The percentage of cells in early and late apoptosis was recorded as 10.10% and 12.36%, respectively. Western Blot Analysis[1] Cell Line: BxPC3 cell Concentration: 1 μM Incubation Time: 48 hours Result: The expression of caspase 3 and cleaved-caspase 3 significantly increased. |
| References |
| Molecular Formula | C43H40F2N10O10S |
|---|---|
| Molecular Weight | 926.90 |