PROTAC BRD4 Degrader-15
Modify Date: 2024-01-12 12:02:51
PROTAC BRD4 Degrader-15 structure
|
Common Name | PROTAC BRD4 Degrader-15 | ||
|---|---|---|---|---|
| CAS Number | 2417370-67-1 | Molecular Weight | 1149.29 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C57H62F2N10O10S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PROTAC BRD4 Degrader-15PROTAC BRD4 Degrader-15 is a potent BRD4 degrader, with IC50s of 7.2 nM and 8.1 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-15 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells[1]. |
| Name | PROTAC BRD4 Degrader-15 |
|---|
| Description | PROTAC BRD4 Degrader-15 is a potent BRD4 degrader, with IC50s of 7.2 nM and 8.1 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-15 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells[1]. |
|---|---|
| Related Catalog | |
| Target |
BRD4 BD1:7.2 nM (IC50) BRD4 BD2:8.1 nM (IC50) |
| In Vitro | PROTAC BRD4 Degrader-15 (compound 13) (4 h) inhibits suppresses MYC gene transcript in MV4-11 AML cells, with an IC50 of 15 nM[1]. PROTAC BRD4 Degrader-15 (6 days) inhibits the proliferation of HL-60 and PC3-S1 cells, with an IC50 of 4.2 nM and 91 nM[1]. |
| References |
| Molecular Formula | C57H62F2N10O10S2 |
|---|---|
| Molecular Weight | 1149.29 |
| Storage condition | 2-8°C |