SARS-CoV-2 Mpro-IN-2
Modify Date: 2024-01-03 17:08:53
SARS-CoV-2 Mpro-IN-2 structure
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Common Name | SARS-CoV-2 Mpro-IN-2 | ||
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| CAS Number | 2768834-39-3 | Molecular Weight | 475.39 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H20Cl2N4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SARS-CoV-2 Mpro-IN-2SARS-CoV-2 Mpro-IN-2 (compound GC-14) is a selective, low cytotoxic and non-covalent Mpro inhibitor (IC50=0.40 μM) with good anti-SARS-CoV-2 activity (EC50=1.1 μM). SARS-CoV-2 Mpro-IN-2 can be used in COVID-19 studies[1]. |
| Name | SARS-CoV-2 Mpro-IN-2 |
|---|
| Description | SARS-CoV-2 Mpro-IN-2 (compound GC-14) is a selective, low cytotoxic and non-covalent Mpro inhibitor (IC50=0.40 μM) with good anti-SARS-CoV-2 activity (EC50=1.1 μM). SARS-CoV-2 Mpro-IN-2 can be used in COVID-19 studies[1]. |
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| Related Catalog | |
| Target |
Mpro:0.40 μM (IC50) |
| In Vitro | SARS-CoV-2 Mpro-IN-2 (0.01-100 μM; 4 h) shows low cytotoxicity in Vero E6 cells[1]. Cell Cytotoxicity Assay[1] Cell Line: Vero E6 cells Concentration: 0.01-100 μM Incubation Time: 4 h Result: Exhibited low cytotoxicity with a CC50 value of more than 100 μM. |
| In Vivo | SARS-CoV-2 Mpro-IN-2 (2 mg/kg; i.v.; single) exhibits clearance rate (CL), mean residence time (MRT), and half-life (t1/2) are 3140 mL/h/kg, 0.40 h, and 0.36 h, respectively[1]. SARS-CoV-2 Mpro-IN-2 (10 mg/kg; p.o.; single) is rapidly absorbed, with a time-to-maximum concentration (Tmax) of 0.5 h, and shows a moderate pharmacokinetic profile including a favorable t1/2 (1.73 h), a maximum concentration (Cmax) 74.6 ng/mL, and an area under curve (AUC0-t) of 235 ng h/mL[1]. Animal Model: Male Sprague-Dawley rats[1]. Dosage: 2 mg/kg (for i.v.); 10 mg/kg (for p.o.). Administration: Intravenous injection or oral administration; single. Result: 1.19Pharmacokinetic Parameters of SARS-CoV-2 Mpro-IN-2 in Male Sprague-Dawley rats[1]. IV (2 mg/kg) PO (10 mg/kg) t1/2 (h) 0.36 1.73 Tmax (h) 0.08 0.5 Cmax (ng/mL) 1310 74.6 C0 (ng/mL) 1760 - AUC0-t (ng/mL•h) 627 235 AUC0-∞ (ng/mL•h) 637 230 MRT0-∞ (h) 0.40 2.45 CL (mL/h/kg) 3140 - F (%) - 7.2 |
| References |
| Molecular Formula | C22H20Cl2N4O2S |
|---|---|
| Molecular Weight | 475.39 |