INO-1001

Modify Date: 2024-01-02 09:27:37

INO-1001 Structure
INO-1001 structure
Common Name INO-1001
CAS Number 501364-82-5 Molecular Weight 439.52700
Density N/A Boiling Point N/A
Molecular Formula C23H25N3O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of INO-1001


INO-1001 is a potent and selective Poly (ADP-ribose) polymerase (PARP) inhibitor with an IC50 of 0.05-1 μM. INO-1001 is a potent enhancer of radiation sensitivity and enhances radiation-induced cell killing by interfering with DNA repair mechanisms, resulting in necrotic cell death[1]. INO-1001 has anti-tumor effects[2].

 Names

Name N-[3-(4-Morpholinyl)propyl]-5-oxo-6,11-dihydro-5H-indeno[1,2-c]is oquinoline-9-sulfonamide
Synonym More Synonyms

 INO-1001 Biological Activity

Description INO-1001 is a potent and selective Poly (ADP-ribose) polymerase (PARP) inhibitor with an IC50 of 0.05-1 μM. INO-1001 is a potent enhancer of radiation sensitivity and enhances radiation-induced cell killing by interfering with DNA repair mechanisms, resulting in necrotic cell death[1]. INO-1001 has anti-tumor effects[2].
Related Catalog
Target

PARP:0.05-1 μM (IC50)

References

[1]. Brock WA, et al. Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase. Cancer Lett. 2004 Mar 18;205(2):155-60.

[2]. Mason KA, et al. INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase, enhances tumor response to doxorubicin. Invest New Drugs. 2008 Feb;26(1):1-5. Epub 2007 Jul 13.

 Chemical & Physical Properties

Molecular Formula C23H25N3O4S
Molecular Weight 439.52700
Exact Mass 439.15700
PSA 100.14000
LogP 3.92180

 Synthetic Route

~54%

INO-1001 Structure

INO-1001

CAS#:501364-82-5

Literature: Inotek Pharmaceutical, Corp. Patent: US2006/19980 A1, 2006 ; Location in patent: Page/Page column 31-33; 54 ;

~42%

INO-1001 Structure

INO-1001

CAS#:501364-82-5

Literature: INOTEK PHARMACEUTICALS CORPORATION Patent: WO2005/82368 A1, 2005 ; Location in patent: Page/Page column 60; 86-87 ;

~%

INO-1001 Structure

INO-1001

CAS#:501364-82-5

Literature: Jagtap, Prakash G.; Baloglu, Erkan; Southan, Garry J.; Mabley, Jon G.; Li, Hongshan; Zhou, Jing; Van Duzer, John; Salzman, Andrew L.; Szabo, Csaba Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5100 - 5103

~%

INO-1001 Structure

INO-1001

CAS#:501364-82-5

Literature: Jagtap, Prakash G.; Baloglu, Erkan; Southan, Garry J.; Mabley, Jon G.; Li, Hongshan; Zhou, Jing; Van Duzer, John; Salzman, Andrew L.; Szabo, Csaba Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5100 - 5103

~%

INO-1001 Structure

INO-1001

CAS#:501364-82-5

Literature: Jagtap, Prakash G.; Baloglu, Erkan; Southan, Garry J.; Mabley, Jon G.; Li, Hongshan; Zhou, Jing; Van Duzer, John; Salzman, Andrew L.; Szabo, Csaba Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5100 - 5103

 Synonyms

9-[N-(3-[morpholin-4-yl]propyl)-aminosulphonyl]-5,6-dihydro-5-oxo-11H-indeno[1,2-c]isoquinoline
inotec indeno[1,2c]isoquinoline
9H-Xanthene,9-[bis(4-methoxyphenyl)methylene]
9-[N-(3-[morpholino-4-yl]propyl)-aminosulphonyl]-5,6-dihydro-5-oxo-11H-indeno-[1,2-c]isoquinoline
9-<Bis-(4-methoxy-phenyl)-methylen>-xanthen
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Price: ¥3850/10 mM * 1 mL in DMSO

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