INO-1001 structure
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Common Name | INO-1001 | ||
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CAS Number | 501364-82-5 | Molecular Weight | 439.52700 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C23H25N3O4S | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of INO-1001INO-1001 is a potent and selective Poly (ADP-ribose) polymerase (PARP) inhibitor with an IC50 of 0.05-1 μM. INO-1001 is a potent enhancer of radiation sensitivity and enhances radiation-induced cell killing by interfering with DNA repair mechanisms, resulting in necrotic cell death[1]. INO-1001 has anti-tumor effects[2]. |
Name | N-[3-(4-Morpholinyl)propyl]-5-oxo-6,11-dihydro-5H-indeno[1,2-c]is oquinoline-9-sulfonamide |
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Synonym | More Synonyms |
Description | INO-1001 is a potent and selective Poly (ADP-ribose) polymerase (PARP) inhibitor with an IC50 of 0.05-1 μM. INO-1001 is a potent enhancer of radiation sensitivity and enhances radiation-induced cell killing by interfering with DNA repair mechanisms, resulting in necrotic cell death[1]. INO-1001 has anti-tumor effects[2]. |
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Related Catalog | |
Target |
PARP:0.05-1 μM (IC50) |
References |
Molecular Formula | C23H25N3O4S |
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Molecular Weight | 439.52700 |
Exact Mass | 439.15700 |
PSA | 100.14000 |
LogP | 3.92180 |
~54% INO-1001 CAS#:501364-82-5 |
Literature: Inotek Pharmaceutical, Corp. Patent: US2006/19980 A1, 2006 ; Location in patent: Page/Page column 31-33; 54 ; |
~42% INO-1001 CAS#:501364-82-5 |
Literature: INOTEK PHARMACEUTICALS CORPORATION Patent: WO2005/82368 A1, 2005 ; Location in patent: Page/Page column 60; 86-87 ; |
~% INO-1001 CAS#:501364-82-5 |
Literature: Jagtap, Prakash G.; Baloglu, Erkan; Southan, Garry J.; Mabley, Jon G.; Li, Hongshan; Zhou, Jing; Van Duzer, John; Salzman, Andrew L.; Szabo, Csaba Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5100 - 5103 |
~% INO-1001 CAS#:501364-82-5 |
Literature: Jagtap, Prakash G.; Baloglu, Erkan; Southan, Garry J.; Mabley, Jon G.; Li, Hongshan; Zhou, Jing; Van Duzer, John; Salzman, Andrew L.; Szabo, Csaba Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5100 - 5103 |
~% INO-1001 CAS#:501364-82-5 |
Literature: Jagtap, Prakash G.; Baloglu, Erkan; Southan, Garry J.; Mabley, Jon G.; Li, Hongshan; Zhou, Jing; Van Duzer, John; Salzman, Andrew L.; Szabo, Csaba Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5100 - 5103 |
9-[N-(3-[morpholin-4-yl]propyl)-aminosulphonyl]-5,6-dihydro-5-oxo-11H-indeno[1,2-c]isoquinoline |
inotec indeno[1,2c]isoquinoline |
9H-Xanthene,9-[bis(4-methoxyphenyl)methylene] |
9-[N-(3-[morpholino-4-yl]propyl)-aminosulphonyl]-5,6-dihydro-5-oxo-11H-indeno-[1,2-c]isoquinoline |
9-<Bis-(4-methoxy-phenyl)-methylen>-xanthen |